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Article

The genetic toxicity effects of lamivudine and stavudine antiretroviral agents.

Expert opinion on drug safety - 1 Sept 2010

Guimarães Nilza Nascimento, de Andrade Heloísa Helena Rodrigues, Lehmann Maurício, Dihl Rafael Rodrigues, Cunha Kênya Silva

Abstract excerpt

IMPORTANCE OF THE FIELD: The nucleoside reverse transcriptase inhibitors (NRTIs) are used in antiretroviral therapy worldwide for the treatment of HIV infections. These drugs act by blocking reverse transcriptase enzyme activity, causing pro-viral DNA chain termination. As a consequence, NRTIs could cause genomic instability and loss of heterozygosity. AREAS COVERED IN THIS REVIEW: This review highlights the...

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PMID: 20377473
DOI: 10.1517/14740331003702384

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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