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Article

A brief overview of mechanisms of mitochondrial toxicity from NRTIs.

Environmental and molecular mutagenesis - 1 Jan 2000

Kohler James J, Lewis William

Abstract excerpt

Nucleoside reverse transcriptase inhibitors (NRTIs) in combinations with other antiretrovirals (highly active antiretroviral therapy, HAART) are the cornerstones of AIDS therapy, turning HIV infection into a manageable clinical entity. Despite the initial positive impact of NRTIs, therapeutic experience revealed serious side effects that appeared to originate in the mitochondria and which ultimately manifested as...

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Identifiers

PMID: 16758472
DOI: 10.1002/em.20223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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