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Article

Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA

7 Oct 2010

Abstract excerpt

IMPORTANCE OF THE FIELD: HIV/AIDS is a worldwide epidemic. While there remains no cure for the HIV-1 infection, nucleoside reverse transcriptase inhibitors (NRTIs) have helped transform the HIV-1 infection from a lethal disease into a chronic illness. Though NRTIs inhibit HIV-1 replication, they exhibit side effects in human tissues that appear to result from NRTI inhibition of human mitochondrial polymerase γ...

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Identifiers

PMID: 20929279
DOI: 10.1517/17425255.2010.526602

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