Article
Association of prostate cancer risk with SNPs in regions containing androgen receptor binding sites captured by ChIP-On-chip analyses.
The Prostate - 1 Mar 2012
Lu Yizhen, Sun Jielin, Kader Andrew K, Kim Seong-Tae, Kim Jin-Woo, Liu Wennuan, Sun Jishan, Lu Daru, Feng Junjie, Zhu Yi, Jin Tao, Zhang Zheng, Dimitrov Latchezar, Lowey James, Campbell Kevin, Suh Edward, Duggan David, Carpten John, Trent Jeffrey M, Gronberg Henrik, Zheng S Lilly, Isaacs William B, Xu Jianfeng
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified approximately three dozen single nucleotide polymorphisms (SNPs) consistently associated with prostate cancer (PCa) risk. Despite the reproducibility of these associations, the molecular mechanism for most of these SNPs has not been well elaborated as most lie within non-coding regions of the genome. Androgens play a key role in prostate...
Topics
- Base Sequence
- Binding Sites
- Case-Control Studies
- Cohort Studies
- DNA, Neoplasm
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male