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Article

Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.

Nature medicine - 1 Jan 2004

Yasoda Akihiro, Komatsu Yasato, Chusho Hideki, Miyazawa Takashi, Ozasa Ami, Miura Masako, Kurihara Tatsuya, Rogi Tomohiro, Tanaka Shoji, Suda Michio, Tamura Naohisa, Ogawa Yoshihiro, Nakao Kazuwa

Abstract excerpt

Achondroplasia is the most common genetic form of human dwarfism, for which there is presently no effective therapy. C-type natriuretic peptide (CNP) is a newly identified molecule that regulates endochondral bone growth through GC-B, a subtype of particulate guanylyl cyclase. Here we show that targeted overexpression of CNP in chondrocytes counteracts dwarfism in a mouse model of achondroplasia with activated...

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Source

Identifiers

PMID: 14702637
DOI: 10.1038/nm971

Genes

CNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.PMID 14702637Read ↗

[Genetic basis for skeletal disease. CNP therapy for achondroplasia].Semantic proximity Read ↗

Achondroplasia: pathogenesis and implications for future treatment.Semantic proximity Read ↗

Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia.Semantic proximity Read ↗

Translational research of C-type natriuretic peptide (CNP) into skeletal dysplasias.Semantic proximity Read ↗

Dwarfism and early death in mice lacking C-type natriuretic peptideSemantic proximity Read ↗

Novel therapeutic approaches for the treatment of achondroplasia.Semantic proximity Read ↗

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis.Semantic proximity Read ↗

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 GeneSemantic proximity Read ↗

Role of the natriuretic peptide system in normal growth and growth disorders.Semantic proximity Read ↗

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth.Semantic proximity Read ↗

FGFR3 targeting strategies for achondroplasia.Semantic proximity Read ↗

CNP, the Third Natriuretic Peptide: Its Biology and Significance to the Cardiovascular SystemSemantic proximity Read ↗

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