Article
Genetic and functional analysis of chymotrypsin-like protease (CTRL) in chronic pancreatitis.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Dec 2023
Eiseler Katharina, Neppl Lea, Schmidt Andreas W, Rauscher Beate, Ewers Maren, Masson Emmanuelle, Chen Jian-Min, Férec Claude, Rebours Vinciane, Grammatikopoulos Tassos, Foskett Pierre, Greenhalf William, Halloran Christopher, Neoptolemos John, Haack Tobias B, Ossowski Stephan, Sturm Marc, Rosendahl Jonas, Laumen Helmut, Witt Heiko
Abstract excerpt
BACKGROUND: Genetic predisposition is crucial in the pathogenesis of early-onset chronic pancreatitis (CP). So far, several genetic alterations have been identified as risk factors, predominantly in genes encoding digestive enzymes. However, many early-onset CP cases have no identified underlying cause. Chymotrypsins are a family of serine proteases that can cleave trypsinogen and lead to its degradation. Because...
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