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Article

Risk of chronic pancreatitis in carriers of loss-of-function CTRC variants: A meta-analysis.

PloS one - 1 Jan 2022

Takáts Amanda, Berke Gergő, Gede Noémi, Németh Balázs Csaba, Witt Heiko, Głuszek Stanisław, Rygiel Agnieszka Magdalena, Hegyi Péter, Sahin-Tóth Miklós, Hegyi Eszter

Abstract excerpt

The digestive protease chymotrypsin C (CTRC) protects the pancreas against pancreatitis by degrading potentially harmful trypsinogen. Loss-of-function genetic variants in CTRC increase risk for chronic pancreatitis (CP) with variable effect size, as judged by the reported odds ratio (OR) values. Here, we performed a meta-analysis of published studies on four variants that alter the CTRC amino-acid sequence, are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35594281
DOI: 10.1371/journal.pone.0268859
PMCID: PMC9122191

Genes

CP
CTRC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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