Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations.

doi:10.1158/1535-7163.MCT-14-0892

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Article

Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations.

Molecular cancer therapeutics - 1 Aug 2015

Bonelli Mara A, Cavazzoni Andrea, Saccani Francesca, Alfieri Roberta R, Quaini Federico, La Monica Silvia, Galetti Maricla, Cretella Daniele, Caffarra Cristina, Madeddu Denise, Frati Caterina, Lagrasta Costanza Annamaria, Falco Angela, Rossetti Pietro, Fumarola Claudia, Tiseo Marcello, Petronini Pier Giorgio, Ardizzoni Andrea

Abstract excerpt

A prominent role in the pathogenesis of squamous cell carcinoma of the lung (SQCLC) has been attributed to the aberrant activation of the PI3K signaling pathway, due to amplification or mutations of the p110α subunit of class I phosphatidylinositol 3-kinase (PIK3CA) gene. The aim of our study was to determine whether different genetic alterations of PIK3CA affect the biologic properties of SQCLC and to evaluate...

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PMID: 26013318
DOI: 10.1158/1535-7163.MCT-14-0892

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