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Article

Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells.

Breast cancer research and treatment - 1 Nov 2008

Zhang Haijun, Liu Gang, Dziubinski Michele, Yang Zengquan, Ethier Stephen P, Wu Guojun

Abstract excerpt

More than 20 different PIK3CA gene mutations were identified in breast cancer with different frequencies. Whether these breast cancer associated mutations have similar biological effects is largely unknown. In this study, we established a novel cell model using the lentivirus system to express 10 different PIK3CA genes (wild type and mutant) based on the human mammary epithelial cell MCF10A. We found that nine...

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PMID: 18074223
DOI: 10.1007/s10549-007-9847-6

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EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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