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Article

Distinct mechanisms for dysfunctions of mutated ryanodine receptor isoforms.

Biochemical and biophysical research communications - 25 Apr 2008

Ogawa Yasuo

Abstract excerpt

Ryanodine receptor (RyR) is the Ca(2+)-induced Ca(2+) release channel in cells. RyR1 and RyR2 are its isoforms expressed in the skeletal and cardiac muscles, respectively. Their missense mutations, which are clustered in three regions that correspond to each other, cause hereditary disorders such as malignant hyperthermia and central core disease in skeletal muscle and catecholaminergic polymorphic ventricular...

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Identifiers

PMID: 18067858
DOI: 10.1016/j.bbrc.2007.11.139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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