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Article

Ca2+ handling abnormalities in early-onset muscle diseases: Novel concepts and perspectives.

Seminars in cell & developmental biology - 1 Apr 2017

Treves Susan, Jungbluth Heinz, Voermans Nicol, Muntoni Francesco, Zorzato Francesco

Abstract excerpt

The physiological process by which Ca2+ is released from the sarcoplasmic reticulum is called excitation-contraction coupling; it is initiated by an action potential which travels deep into the muscle fiber where it is sensed by the dihydropyridine receptor, a voltage sensing L-type Ca2+channel localized on the transverse tubules. Voltage-induced conformational changes in the dihydropyridine receptor activate the...

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PMID: 27427513
DOI: 10.1016/j.semcdb.2016.07.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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