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Stage-Specific Degradation of Cyclin D3 Orchestrates Myelopoiesis and Restrains Myeloproliferative Neoplasm Development.

Cancer research - 14 Aug 2026

Mucha Bartosz, Tarallo Vincenzo, Abbas Ata, Hall Melina, Zhang Shuyuan, Farago Marganit, Phillips-Mason Polly J, Lindley Harrison, Cameron Mark, Zhao Chen, Desai Amar B, Diehl J Alan

Abstract excerpt

Accumulation of D cyclins during the G1-phase of the cell cycle is a key regulatory step that derepresses the transcriptional program required for DNA replication, facilitating S-phase entry. Among the three D cyclins, cyclin D3 predominates in hematopoietic cells. Accordingly, cyclin D3 mutations are implicated in lymphoid malignancies. In this study, we provided evidence demonstrating a critical role for cyclin...

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Cell Differentiation
Hematopoietic Stem Cells
Mice
Mutation
Myelopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Disorders

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Open in PubMed Open full text

Identifiers

PMID: 42223968
DOI: 10.1158/0008-5472.CAN-25-4990
PMCID: PMC13312222

Genes

FOXM1
PRMT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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