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Article

Constitutive turnover of cyclin E by Cul3 maintains quiescence.

Molecular and cellular biology - 1 May 2007

McEvoy Justina D, Kossatz Uta, Malek Nisar, Singer Jeffrey D

Abstract excerpt

Two distinct pathways for the degradation of mammalian cyclin E have previously been described. One pathway is induced by cyclin E phosphorylation and is dependent on the Cul1/Fbw7-based E3 ligase. The other pathway is dependent on the Cul3-based E3 ligase, but the mechanistic details of this pathway have yet to be elucidated. To establish the role of Cul3 in the degradation of cyclin E in vivo, we created a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17339333
DOI: 10.1128/MCB.00720-06
PMCID: PMC1899986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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