Article
Polymorphism in the promoter of the gene for the serotonin transporter affects the age of onset of major depressive disorder in the Japanese population.
Journal of affective disorders - 1 Sept 2015
Watanabe Shin-ya, Iga Jun-ichi, Numata Shusuke, Umehara Hidehiro, Nishi Akira, Kinoshita Makoto, Inoshita Masatoshi, Ohmori Tetsuro
Abstract excerpt
OBJECTIVE: Recent research has suggested that a functional polymorphism in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region, 5HTTLPR) may be implicated in gene-environment interactions leading to major depressive disorder (MDD). METHODS: Our study examined the association between 5HTTLPR and clinical variables of MDD in the Japanese population. We genotyped...
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