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Article

Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese.

PloS one - 1 Jan 2014

Li Ping, Liu Tiantian, Liu Jiajia, Zhang Qing, Lou Fenglan, Kong Feng, Cheng Guanghui, Björkholm Magnus, Zheng Chengyun, Xu Dawei

Abstract excerpt

The serotonin transporter gene (5-HTT)-linked polymorphic region (5-HTTLPR) plays an important role in modulating mood and behavior by regulating 5-HTT expression and thereby controlling the concentration of serotonin (5-HT) in brain synapses: The homozygous shorter allele (S/S) in 5-HTTLPR results in lower 5-HTT expression coupled with stronger psycho-pathological reactions to stressful experiences compared to...

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Identifiers

PMID: 24710073
DOI: 10.1371/journal.pone.0094442
PMCID: PMC3978058

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HTT

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