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Article

Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2011

Mueller Anett, Armbruster Diana, Moser Dirk A, Canli Turhan, Lesch Klaus-Peter, Brocke Burkhard, Kirschbaum Clemens

Abstract excerpt

There has been significant controversy whether stressful life events (SLEs) experienced over the lifespan may elevate the risk of depression in individuals who are homozygous for the short (S) allele of the repeat length polymorphism (5-HTTLPR) in the regulatory region of the serotonin transporter gene (SLC6A4), compared with individuals homozygous for the long (L) allele. On the basis of the hypothesis that age...

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Identifiers

PMID: 21368747
DOI: 10.1038/npp.2011.11
PMCID: PMC3096802

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