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Article

NUP98/11p15 translocations affect CD34+ cells in myeloid and T lymphoid leukemias.

Leukemia research - 1 Jul 2015

Crescenzi Barbara, Nofrini Valeria, Barba Gianluca, Matteucci Caterina, Di Giacomo Danika, Gorello Paolo, Beverloo Berna, Vitale Antonella, Wlodarska Iwona, Vandenberghe Peter, La Starza Roberta, Mecucci Cristina

Abstract excerpt

We assessed lineage involvement by NUP98 translocations in myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML), and T-cell acute lymphoblastic leukaemia (T-ALL). Single cell analysis by FICTION (Fluorescence Immunophenotype and Interphase Cytogenetics as a Tool for Investigation of Neoplasms) showed that, despite diverse partners, i.e. NSD1, DDX10, RAP1GDS1, and LNP1, NUP98 translocations always...

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Topics

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Share to Antigens, CD34
Share to Chromosomes, Human, Pair 11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myeloid, Acute

Share to Leukemia, T-Cell

Share to Nuclear Pore Complex Proteins

Share to Polymorphism, Single Nucleotide

Share to Translocation, Genetic

Source

Identifiers

PMID: 26004809
DOI: 10.1016/j.leukres.2015.04.014

Genes

NUP98
DDX10
FLT3
LNP1
MYB
NOTCH1
NSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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