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Article

Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2015

Kim Jongseong, Hudson Nathan E, Springer Timothy A

Abstract excerpt

Mutations in the ultralong vascular protein von Willebrand factor (VWF) cause the common human bleeding disorder, von Willebrand disease (VWD). The A1 domain in VWF binds to glycoprotein Ibα (GPIbα) on platelets, in a reaction triggered, in part, by alterations in flow during bleeding. Gain-of-function mutations in A1 and GPIbα in VWD suggest conformational regulation. We report that force application switches A1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25810255
DOI: 10.1073/pnas.1501689112
PMCID: PMC4403213

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Force-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.PMID 25810255Read ↗

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