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Article

Probing the structure of F-actin: cross-links constrain atomic models and modify actin dynamics.

Journal of molecular biology - 7 Sept 2001

Orlova A, Galkin V E, VanLoock M S, Kim E, Shvetsov A, Reisler E, Egelman E H

Abstract excerpt

Cross-links between protomers in F-actin can be used as a very sensitive probe of both the dynamics and structure of F-actin. We have characterized filaments formed from a previously described yeast actin Q41C mutant, where disulfide bonds can be formed between the Cys41 that is introduced into subdomain-2 and Cys374 on an adjacent protomer. We find that the distribution of cross-linked n-mers shows no...

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Source

Identifiers

PMID: 11545588
DOI: 10.1006/jmbi.2001.4945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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