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Article

Three-dimensional (3D) culture of bone-derived human 786-O renal cell carcinoma retains relevant clinical characteristics of bone metastases.

Cancer letters - 28 Aug 2015

Pan Tianhong, Fong Eliza L S, Martinez Mariane, Harrington Daniel A, Lin Sue-Hwa, Farach-Carson Mary C, Satcher Robert L

Abstract excerpt

Bone metastases from renal cell carcinoma (RCC) are typically lytic, destructive, and resistant to treatment regimens. Current in vitro models for studying metastasis introduce artifacts that limit their usefulness. Many features of tumors growing in bone are lost when human RCC cells are cultured in two-dimensional (2D) plastic substrata. In this study, we established that RCC spheroids, consisting of aggregates...

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Identifiers

PMID: 26004343
DOI: 10.1016/j.canlet.2015.05.019
PMCID: PMC4530612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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