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Article

3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus.

Biomaterials - 1 Apr 2016

Del Bufalo Francesca, Manzo Teresa, Hoyos Valentina, Yagyu Shigeki, Caruana Ignazio, Jacot Jeffrey, Benavides Omar, Rosen Daniel, Brenner Malcolm K

Abstract excerpt

Interactions between malignant and stromal cells and the 3D spatial architecture of the tumor both substantially modify tumor behavior, including the responses to small molecule drugs and biological therapies. Conventional 2D culture systems cannot replicate this complexity. To overcome these limitations and more accurately model solid tumors, we developed a highly versatile 3D PEG-fibrin hydrogel model of human...

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PMID: 26826297
DOI: 10.1016/j.biomaterials.2016.01.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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