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Article

Associations of chemo- and radio-resistant phenotypes with the gap junction, adhesion and extracellular matrix in a three-dimensional culture model of soft sarcoma.

Journal of experimental & clinical cancer research : CR - 10 Jun 2015

Bai Chujie, Yang Min, Fan Zhengfu, Li Shu, Gao Tian, Fang Zhiwei

Abstract excerpt

BACKGROUND: Three-dimensional (3D) culture models are considered to recapitulate the cell microenvironment in solid tumors, including the extracellular matrix (ECM), cell-cell interactions, and signal transduction. These functions are highly correlated with cellular behaviors and contribute to resistances against chemo- and radio-therapies. However, the biochemical effects and mechanisms remain unknown in soft...

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Source

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Identifiers

PMID: 26055407
DOI: 10.1186/s13046-015-0175-0
PMCID: PMC4467058

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LAMA4
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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