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Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

1 Apr 2013

Abstract excerpt

The pronounced biological influence of the tumor microenvironment on cancer progression and metastasis has gained increased recognition over the past decade, yet most preclinical antineoplastic drug testing is still reliant on conventional 2D cell culture systems. Although monolayer cultures recapitulate some of the phenotypic traits observed clinically, they are limited in their ability to model the full range...

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PMID: 23576741
DOI: 10.1073/pnas.1221403110

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