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Cancer Stem Cell Epigenetics And Chemoresistance

1 Oct 2009

Abstract excerpt

Cancer stem cells (CSCs) are thought to sustain cancer progression, metastasis and recurrence after therapy. There is in vitro and in vivo evidence supporting the idea that CSCs are highly chemoresistant. Epigenetic gene regulation is crucial for both stem cell biology and chemoresistance. In this review, we summarize current data on epigenetic mechanisms of chemoresistance in cancer stem cells. We propose a...

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PMID: 22122637
DOI: 10.2217/epi.09.4

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