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DNA Methylation–Targeted Drugs

1 Sept 2017

Abstract excerpt

Targeting DNA hypermethylation, using nucleoside analogs, is an efficient approach to reprogram cancer cell epigenome leading to reduced proliferation, increased differentiation, recognition by the immune system, and ultimately cancer cell death. DNA methyltransferase inhibitors have been approved for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myelogenous leukemia. To...

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PMID: 28926427
DOI: 10.1097/ppo.0000000000000278

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