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Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries

1 Jan 2015

Abstract excerpt

Recent advances in stem cell biology have shed light on how normal stem and progenitor cells can evolve to acquire malignant characteristics during tumorigenesis. The cancer counterparts of normal stem and progenitor cells might be occurred through alterations of stem cell fates including an increase in self-renewal capability and a decrease in differentiation and/or apoptosis. This oncogenic evolution of cancer...

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Share to Autophagy in Disease and Therapy
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PMID: 25621113
DOI: 10.4252/wjsc.v7.i1.137

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