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Article

Reduced serpinB9-mediated caspase-1 inhibition can contribute to autoinflammatory disease.

Oncotarget - 12 Apr 2016

van der Burgh Robert, Meeldijk Jan, Jongeneel Lieneke, Frenkel Joost, Bovenschen Niels, van Gijn Mariëlle, Boes Marianne

Abstract excerpt

Patients who suffer from autoinflammatory disease (AID) exhibit seemingly uncontrolled release of interleukin (IL)-1β. The presence of this inflammatory cytokine triggers immune activation in absence of pathogens and foreign material. The mechanisms that contribute to 'sterile inflammation' episodes in AID patients are not fully understood, although for some AIDs underlying genetic causes have been identified. We...

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Identifiers

PMID: 26992230
DOI: 10.18632/oncotarget.8086
PMCID: PMC4991381

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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