Article
Tracking sub-clonal TP53 mutated tumor cells in human metastatic renal cell carcinoma.
Oncotarget - 7 Aug 2015
Bousquet Guilhem, El Bouchtaoui Morad, Leboeuf Christophe, Battistella Maxime, Varna Mariana, Ferreira Irmine, Plassa Louis-François, Hamdan Diaddin, Bertheau Philippe, Feugeas Jean-Paul, Damotte Diane, Janin Anne
Abstract excerpt
Renal Cell Carcinomas (RCCs) are heterogeneous tumors with late acquisition of TP53 abnormalities during their evolution. They harbor TP53 abnormalities in their metastases. We aimed to study TP53 gene alterations in tissue samples from primary and metastatic RCCs in 36 patients followed up over a median of 4.2 years, and in xenografted issued from primary RCCs. In 36 primary RCCs systematically xenografted in...
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