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Article

Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients

2 May 2011

Abstract excerpt

Renal cell carcinoma (RCC) is an aggressive malignancy with limited responsiveness to existing treatments. In vivo models of human cancer, including RCC, are critical for developing more effective therapies. Unfortunately, current RCC models do not accurately represent relevant properties of the human disease. The goal of this study was to develop clinically relevant animal models of RCC for preclinical...

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PMID: 21710693
DOI: 10.1002/path.2929

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