DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts.

doi:10.2337/db15-0264

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DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts.

Diabetes - 1 Sept 2015

Huang Tao, Zheng Yan, Qi Qibin, Xu Min, Ley Sylvia H, Li Yanping, Kang Jae H, Wiggs Janey, Pasquale Louis R, Chan Andrew T, Rimm Eric B, Hunter David J, Manson JoAnn E, Willett Walter C, Hu Frank B, Qi Lu

Abstract excerpt

The first epigenome-wide association study of BMI identified DNA methylation at an HIF3A locus associated with BMI. We tested the hypothesis that DNA methylation variants are associated with BMI according to intake of B vitamins. In two large cohorts, we found significant interactions between the DNA methylation-associated HIF3A single nucleotide polymorphism (SNP) rs3826795 and intake of B vitamins on 10-year...

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PMID: 26001398
DOI: 10.2337/db15-0264
PMCID: PMC4542450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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