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Vitamin B 12 Supplementation Influences Methylation of Genes Associated with Type 2 Diabetes and Its Intermediate Traits

14 Nov 2017

Abstract excerpt

Aim: To investigate the effect of B12 and/or folic acid supplementation on genome-wide DNA methylation. Methods: We performed Infinium HumanMethylation450 BeadChip (Zymo Research, CA, USA) assay in children supplemented with B12 and/or folic acid (n = 12 in each group) and investigated the functional mechanism of selected differentially methylated loci. Results: We noted significant methylation changes...

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PMID: 29135286
DOI: 10.2217/epi-2017-0102

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