Article
DNA methylation and body-mass index: a genome-wide analysis.
Lancet (London, England) - 7 Jun 2014
Dick Katherine J, Nelson Christopher P, Tsaprouni Loukia, Sandling Johanna K, Aïssi Dylan, Wahl Simone, Meduri Eshwar, Morange Pierre-Emmanuel, Gagnon France, Grallert Harald, Waldenberger Melanie, Peters Annette, Erdmann Jeanette, Hengstenberg Christian, Cambien Francois, Goodall Alison H, Ouwehand Willem H, Schunkert Heribert, Thompson John R, Spector Tim D, Gieger Christian, Trégouët David-Alexandre, Deloukas Panos, Samani Nilesh J
Abstract excerpt
BACKGROUND: Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and body-mass index (BMI) have been identified, little is known about epigenetic changes related to BMI. We undertook a genome-wide analysis of methylation at CpG sites in relation to BMI. METHODS: 479 individuals of...
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