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Article

DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

16 Nov 2020

Abstract excerpt

Abstract Background One of the major challenges in obesity treatment is to explain the high variability in the individual’s response to specific dietary and physical activity interventions. With this study, we tested the hypothesis that specific DNA methylation changes reflect individual responsiveness to lifestyle intervention and may serve as epigenetic predictors for a successful weight-loss. Methods We...

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PMID: 33198820
DOI: 10.1186/s13073-020-00794-7

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