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Article

Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2021

Guo Cuilian, Liu Jinxin, Li Huqun

Abstract excerpt

AIMS: The present study aimed to investigate the possible effects of metformin on the olanzapine-induced insulin resistance in rats. METHODS: Rats were randomly divided into three groups: the control (Control) group, the olanzapine (Ola) group and the olanzapine + metformin (Ola + Met) group. Rats in the Ola group received olanzapine (8 mg/kg/day) intraperitoneally while rats in the Ola + Met group received...

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PMID: 33217690
DOI: 10.1016/j.biopha.2020.110912

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