Article
Metformin affects macrophages' phenotype and improves the activity of glutathione peroxidase, superoxide dismutase, catalase and decreases malondialdehyde concentration in a partially AMPK-independent manner in LPS-stimulated human monocytes/macrophages.
Pharmacological reports : PR - 1 Jun 2014
Bułdak Łukasz, Łabuzek Krzysztof, Bułdak Rafał Jakub, Kozłowski Michał, Machnik Grzegorz, Liber Sebastian, Suchy Dariusz, Duława-Bułdak Anna, Okopień Bogusław
Abstract excerpt
BACKGROUND: Diabetic patients experience accelerated atherosclerosis. Metformin is a cornerstone of the current therapy of type 2 diabetes. Macrophages are the key cells associated with the development of atherosclerotic plaques. Therefore, our aim was to assess the in vitro effects of metformin on macrophages and its influence on the mechanisms involved in the development of atherosclerosis. MATERIALS AND...
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