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Article

Role of cMET in the Development and Progression of Colorectal Cancer

3 Sept 2013

Abstract excerpt

Mesenchymal-epithelial transition (MET) is a member of a distinct subfamily of heterodimeric receptor tyrosine kinase receptors that specifically binds the hepatocyte growth factor (HGF). Binding to HGF leads to receptor dimerization/multimerization and phosphorylation, resulting in its catalytic activation. MET activation drives the malignant progression of several tumor types, including colorectal cancer (CRC),...

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Identifiers

PMID: 24005867
DOI: 10.3390/ijms140918056

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