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Article

Generation of meiomaps of genome-wide recombination and chromosome segregation in human oocytes.

Nature protocols - 1 Jul 2016

Ottolini Christian S, Capalbo Antonio, Newnham Louise, Cimadomo Danilo, Natesan Senthilkumar A, Hoffmann Eva R, Ubaldi Filippo M, Rienzi Laura, Handyside Alan H

Abstract excerpt

We have developed a protocol for the generation of genome-wide maps (meiomaps) of recombination and chromosome segregation for the three products of human female meiosis: the first and second polar bodies (PB1 and PB2) and the corresponding oocyte. PB1 is biopsied and the oocyte is artificially activated by exposure to calcium ionophore, after which PB2 is biopsied and collected with the corresponding oocyte. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27310263
DOI: 10.1038/nprot.2016.075

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