Article
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
The New England journal of medicine - 21 May 2015
Krug Norbert, Hohlfeld Jens M, Kirsten Anne-Marie, Kornmann Oliver, Beeh Kai M, Kappeler Dominik, Korn Stephanie, Ignatenko Stanislav, Timmer Wolfgang, Rogon Cordelia, Zeitvogel Jana, Zhang Nan, Bille Joachim, Homburg Ursula, Turowska Agnieszka, Bachert Claus, Werfel Thomas, Buhl Roland, Renz Jonas, Garn Holger, Renz Harald
Abstract excerpt
BACKGROUND: The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of GATA3, an important transcription factor of the Th2 pathway, may be beneficial. We evaluated the safety and efficacy of SB010, a novel DNA enzyme (DNAzyme) that is able to cleave and inactivate GATA3 messenger RNA (mRNA). METHODS: We...
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