Article

Eosinophil Counts in Adults with Asthma Treated with Anti-IL-4Rα Rademikibart in a Randomized Trial

2025-10-14

Abstract excerpt

<h4>Background: </h4> Inhibition of IL-4Rα has been associated with increased eosinophil counts in Phase 3 trials. Rademikibart, a next-generation IL-4Rα inhibitor, resulted in rapid lung function improvements, sustained across 24 weeks of treatment, in adults with uncontrolled moderate-to-severe asthma during the CBP-201-WW002 Phase 2b trial. To determine if hypereosinophilia is a class (IL-4Rα inhibitor) effect,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 191c6127-58a2-503a-b7ee-c604df75566e
DOI: 10.22541/au.176043277.77613739/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Eosinophil Counts in Adults with Asthma Treated with Anti-IL-4Rα Rademikibart in a Randomized TrialDOI 10.22541/au.176043277.77613739/v1Read

Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic PhenotypeSemantic proximity Read

Efficacy and safety of Depemokimab in asthma with eosinophilic phenotype: a systematic review and meta-analysis of randomized controlled trials.Semantic proximity Read

Variability in Blood Eosinophil Counts in Patients with Eosinophilic Asthma.Semantic proximity Read

Mepolizumab real-world effectiveness in severe asthma with an eosinophilic phenotype and overlapping severe allergic asthma.Semantic proximity Read

Surface Expression of CD63 and HLA-DR in circulating eosinophils correlates with Improved Clinical Control After Treatment Optimization in asthmaSemantic proximity Read

Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotypeSemantic proximity Read

Reslizumab (Cinqair) for severe eosinophilic asthma.Semantic proximity Read

Benralizumab for the add-on maintenance treatment of patients with severe asthma aged 12 years and older with an eosinophilic phenotype.Semantic proximity Read

Monitoring eosinophils to guide therapy with Biologics in Asthma: does the compartment matter?Semantic proximity Read

Phase 2a, randomized, double-blind, placebo-controlled, multicentre, parallel-group study of an H4 R-antagonist (JNJ-39758979) in adults with uncontrolled asthma.Semantic proximity Read

Biologics for Eosinophilic Oesophagitis: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsSemantic proximity Read

Safety of humanized monoclonal antibodies against IL-5 in asthma: focus on reslizumab.Semantic proximity Read