Article

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

2022-05-19

Abstract excerpt

Allergic asthma is a complex disease characterized by dyspnea, coughing, chest tightness and airway remodeling, for which there is no cure and is symptomatically treated with inhaled β2-agonist and/or corticosteroids. Molecular mechanisms underlying its complex pathogenesis are not fully understood. However, the 8-oxoguanine DNA glycosylase-1 (OGG1), a DNA repair protein may play a central role, as OGG1 deficiency...

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Literature Corpus work: b5dde96c-ef2a-5d5e-a5af-65c3dbadb128
DOI: 10.1101/2022.05.17.492235

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