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Article

Expression profile of host restriction factors in HIV-1 elite controllers

16 Oct 2013

Abstract excerpt

BACKGROUND: Several host-encoded antiviral factors suppress HIV-1 replication in a cell-autonomous fashion in vitro. The relevance of these defenses to the control of HIV-1 in vivo remains to be elucidated. We hypothesized that cellular restriction of HIV-1 replication plays a significant role in the observed suppression of HIV-1 in "elite controllers", individuals who maintain undetectable levels of viremia in...

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PMID: 24131498
DOI: 10.1186/1742-4690-10-106

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