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Article

Selective striatal mtDNA depletion in end-stage Huntington's disease R6/2 mice.

Experimental neurology - 1 Apr 2015

Hering Tanja, Birth Nathalie, Taanman Jan-Willem, Orth Michael

Abstract excerpt

In Huntington's disease (HD) the striatum and cortex seem particularly vulnerable. Mitochondrial dysfunction can also cause neurodegeneration with prominent striatal involvement very similar to HD. We first examined if mitochondrial biogenesis, mitochondrial DNA (mtDNA) transcription, and the implications for mitochondrial respiratory chain (MRC) assembly and function differ between the striatum and cortex...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25682918
DOI: 10.1016/j.expneurol.2015.02.004

Genes

PGC
TFAM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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