Article

Bioenergetic dysregulation in the basal ganglia and cerebellum of patients with premanifest and manifest Huntington’s disease

2026-01-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. While early striatal degeneration is a well-established hallmark, emerging evidence points to broader network-level dysfunction involving the cerebellum and profound alterations in mitochondrial energy metabolism. However, in...

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Literature Corpus work: a1c7bc21-62f0-5819-a528-aa0e12eb7205
DOI: 10.64898/2026.01.12.26343913

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