Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.

Journal of neurochemistry - 1 Mar 2004

Klivenyi Peter, Starkov Anatoly A, Calingasan Noel Y, Gardian Gabrielle, Browne Susan E, Yang Lichuan, Bubber Parvesh, Gibson Gary E, Patel Mulchand S, Beal M Flint

Abstract excerpt

Altered energy metabolism, including reductions in activities of the key mitochondrial enzymes alpha-ketoglutarate dehydrogenase complex (KGDHC) and pyruvate dehydrogenase complex (PDHC), are characteristic of many neurodegenerative disorders including Alzheimer's Disease (AD), Parkinson's disease (PD) and Huntington's disease (HD). Dihydrolipoamide dehydrogenase is a critical subunit of KGDHC and PDHC. We tested...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caudate Nucleus
Share to Corpus Striatum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dihydrolipoamide Dehydrogenase

Share to Nitro Compounds

Share to Propionates

Share to Putamen

Share to Pyruvate Dehydrogenase Complex

Share to Substantia Nigra

Source

Identifiers

PMID: 15009635
DOI: 10.1046/j.1471-4159.2003.02263.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity.PMID 15009635Read ↗

Mice deficient in dihydrolipoyl succinyl transferase show increased vulnerability to mitochondrial toxins.Semantic proximity Read ↗

Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease.Semantic proximity Read ↗

Abnormalities in the tricarboxylic Acid cycle in Huntington disease and in a Huntington disease mouse model.Semantic proximity Read ↗

Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neuronsSemantic proximity Read ↗

Suppression of the dihydrolipoamide dehydrogenase gene ( <i>dld-1</i> ) protects against the toxicity of human amyloid beta in <i>C. elegans</i> model of Alzheimer’s diseaseSemantic proximity Read ↗

Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.Semantic proximity Read ↗

Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.Semantic proximity Read ↗

Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s DiseaseSemantic proximity Read ↗

Oxidative metabolism in YAC128 mouse model of Huntington's disease.Semantic proximity Read ↗

Metabolic Divergence Between Healthy and Conditional Presenilin-1/2 knockout Dementia Model Mice under Chronic Nicotine exposureSemantic proximity Read ↗

Reduced levels of dopamine and altered metabolism in brains of HPRT knock-out rats: a new rodent model of Lesch-Nyhan Disease.Semantic proximity Read ↗

A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.