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Article

Nonadditive Effects of Genes in Human Metabolomics.

Genetics - 1 Jul 2015

Tsepilov Yakov A, Shin So-Youn, Soranzo Nicole, Spector Tim D, Prehn Cornelia, Adamski Jerzy, Kastenmüller Gabi, Wang-Sattler Rui, Strauch Konstantin, Gieger Christian, Aulchenko Yurii S, Ried Janina S

Abstract excerpt

Genome-wide association studies (GWAS) are widely applied to analyze the genetic effects on phenotypes. With the availability of high-throughput technologies for metabolite measurements, GWAS successfully identified loci that affect metabolite concentrations and underlying pathways. In most GWAS, the effect of each SNP on the phenotype is assumed to be additive. Other genetic models such as recessive, dominant,...

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Identifiers

PMID: 25977471
DOI: 10.1534/genetics.115.175760
PMCID: PMC4512538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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