Article
Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2.
PloS one - 1 Jan 2015
Blein Sophie, Barjhoux Laure, Damiola Francesca, Dondon Marie-Gabrielle, Eon-Marchais Séverine, Marcou Morgane, Caron Olivier, Lortholary Alain, Buecher Bruno, Vennin Philippe, Berthet Pascaline, Noguès Catherine, Lasset Christine, Gauthier-Villars Marion, Mazoyer Sylvie, Stoppa-Lyonnet Dominique, Andrieu Nadine, Thomas Gilles, Sinilnikova Olga M, Cox David G
Abstract excerpt
Breast Cancer is a complex multifactorial disease for which high-penetrance mutations have been identified. Approaches used to date have identified genomic features explaining about 50% of breast cancer heritability. A number of low- to medium penetrance alleles (per-allele odds ratio < 1.5 and 4.0, respectively) have been identified, suggesting that the remaining heritability is likely to be explained by the...
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