Article
Alcohol consumption and breast tumor mitochondrial DNA mutations.
Breast cancer research and treatment - 1 Jun 2010
Platek Mary E, Shields Peter G, Tan Duanjun, Marian Catalin, Bonner Matthew R, McCann Susan E, Nie Jing, Wilding Gregory E, Ambrosone Christine, Millen Amy E, Trevisan Maurizio, Russell Marcia, Nochajski Thomas H, Edge Stephen B, Winston Janet, Freudenheim Jo L
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are frequent in breast tumors, but the etiology of these mutations is unknown. We hypothesized that these mutations are associated with exposures that affect oxidative stress such as alcohol metabolism. Using archived tumor blocks from incident breast cancer cases in a case control study, the Western New York Exposures and Breast Cancer (WEB) study, analysis of mtDNA mutations...
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