Article
CYP3A5 polymorphism and the ethnic differences in cyclosporine pharmacokinetics in healthy subjects.
Therapeutic drug monitoring - 1 Oct 2004
Min David I, Ellingrod Vicki L, Marsh Sharon, McLeod Howard
Abstract excerpt
To determine the relationship between CYP3A5 polymorphism and cyclosporine pharmacokinetic parameters among healthy volunteers, an oral cyclosporine (CsA) pharmacokinetic study was performed in 16 healthy subjects. Blood CsA concentrations were measured by high-performance liquid chromatography. Concentration-versus-time data were analyzed by a noncompartmental method using WinNonLin, and the blood samples were...
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