Article
Japanese Society of Medical Oncology Clinical Guidelines: RAS (KRAS/NRAS) mutation testing in colorectal cancer patients.
Cancer science - 1 Mar 2015
Taniguchi Hiroya, Yamazaki Kentaro, Yoshino Takayuki, Muro Kei, Yatabe Yasushi, Watanabe Toshiaki, Ebi Hiromichi, Ochiai Atsushi, Baba Eishi, Tsuchihara Katsuya
Abstract excerpt
The Japanese guidelines for the testing of KRAS mutations in colorectal cancer have been used for the past 5 years. However, new findings of RAS (KRAS/NRAS) mutations that can further predict the therapeutic effects of anti-epidermal growth factor receptor (EGFR) antibody therapy necessitated a revision of the guidelines. The revised guidelines included the following five basic requirements for RAS mutation...
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