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Article

Development and validation of a rapid and reliable real-time PCR method for CYP3A5 genotyping.

Clinical laboratory - 1 Jan 2015

Eidens Moritz, Weise Alexander, Klemm Marco, Fleischer Merle, Prause Stefan

Abstract excerpt

BACKGROUND: A prominent example for inter-individual differences in drug-metabolizing enzymes is the cytochrome P450 family. These monooxygenases comprise enzymes responsible for metabolism of about 90% of common medications. CYP3A5 and CYP3A4 account for 50% of hepatic cytochrome P450 and conversion of about half of all their substrates. CYP3A5 is the predominant extra-hepatic CYP enzyme and shows varying...

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Identifiers

PMID: 25975003
DOI: 10.7754/clin.lab.2014.140827

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